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Centre for Advanced Learning

Dr. Nikil Purushotham

nikil@tlc.edu.in

ABOUT

Dr. Nikil is a curiosity-driven Research Chemist who specializes in the design, synthesis, purification and characterization of peptide conjugates, along with their biological evaluation and molecular docking. With four years of industrial experience in multistep organic synthesis of biologically important compounds and expertise in HPLC techniques, he brings a creative and analytical approach to drug discovery.

Awards and fellowships

  • INSPIRE Fellowship by the Department of Science and Technology (DST), New Delhi, India for doctoral research.
  • ICRAIEST and Syngenta Gold Medals in M.Sc.
  1. Kishan Kumar Gaur, Tejeswara Rao Asuru, Mitul Srivastava, Nitu Singh, Nikil Purushotham, Boja Poojary, Bhabatosh Das, Sankar Bhattacharyya, Shailendra Asthana, and Prasenjit Guchhait, 7D, a small molecule inhibits dengue infection by increasing interferons and neutralizing-antibodies via CXCL4:CXCR3:p38:IRF3 and Sirt1:STAT3 axes respectively. EMBO Mol. Med., 2024, 16, 2376-2401.
  2. Nikil Purushotham, Sachin Bhat, Divyaraj Puthran, Boja Poojary, C. V. Yelamaggad, S. Madan Kumar, Vinuta Kamat, Exploring a new class of efficient boranil-like fluorescent benzoxazaborinines engendered from amino acid counterparts: a synthetic and spectral investigation. Dyes Pigm., 2024, 222, 111878.
  3. Divyaraj Puthran, Vinuta Kamat, Nikil Purushotham, Boja Poojary, Mohammed Shafeeulla Rasheed & Hemant Hegde, Expeditious synthesis and biological evaluation of pyrazole conjugated selenium Lumefantrine analogues. J. Iran. Chem. Soc. 2023, 20, 1903-1916.
  4. Nikil P., Mrityunjay Singh, Bugga Paramesha, Vasantha K., Sharad Wakode., Sanjay K. Banerjee, Boja Poojary, Shailendra Asthana, Design and synthesis of amino acid derivatives of substituted benzimidazoles and pyrazoles as Sirt1 inhibitors. RSC Adv., 2022, 12, 3809-3827. (The article was a part of the themed collection: 2022 RSC Advances Popular Advances Collection)
  5. Divyaraj Puthran, Boja Poojary, Nikil P., An efficient process for the synthesis of novel 1-[(2,7-dichloro-9(4-chlorobenzylidene)-9H-fluoren-4-yl]-2-(methylselanyl)ethanol with excellent HPLC purity. Polycycl. Aromat. Comp. 2020, 42, 727-734.
  6. Divyaraj Puthran, Boja Poojary, Soukhyarani Gopal Nayak, Nikil P., Mohammed Shafeeulla R., Hemant Hegde, Design, synthesis, molecular docking and biological evaluation of novel selenium containing Lumefantrine analogues. J. Heterocycl. Chem. 2020, 57, 1319-1329.
  7. Divyaraj Puthran, Boja Poojary, Soukhyarani Gopal Nayak, Nikil P., Manjunath Bhat, Hemant Hegde, Novel Schiff bases–based thiophenes: Design, synthesis and biological evaluation. J. Chin. Chem. Soc. 2020, 67, 1278-1288.
  8. Nikil P., Boja Poojary, Vaishali Rai, Sowmya P. V., A preliminary study on quinazolinylaminobenzoyl monopeptide esters as effective Gram-positive bacteriostatic agents. Future Med. Chem. 2019, 11, 407-422.
  9. Divyaraj Puthran, Boja Poojary, Nikil P., A facile and practical one-pot synthesis of 2- [(methylselenyl) methyl]benzoic acid. Org. Prep. Proced. Int. 2019, 51, 375-380.
  10. Divyaraj Puthran, Boja Poojary, Nikil P., Nandam Harikrishna, Soukhyarani Gopal Nayak, Vinuta Kamat, Synthesis of novel Schiff bases using 2-amino-5-(3-fluoro-4-methoxyphenyl) thiophene-3-carbonitrile and 1,3-disubstituted pyrazole-4-carboxaldehyde derivatives and their antimicrobial activity. Heliyon 2019, 5, E02233
  11. Nikil P., Boja Poojary, An expeditious synthesis of chiral 1,2,4-oxadiazole peptidomimetics from heteroaroylmonopeptides. ChemistrySelect 2018, 3, 10996-10998.
  12. Nikil P., Boja Poojary, Madan Kumar S., Byrappa K., Synthesis, characterization, crystal structure and Hirshfeld surface analysis of ethyl-2-(4-bromophenyl)-1-cyclohexyl-1H-benzo[d]imidazole-5-carboxylate. Crystallogr. Rep. 2017, 63, 574-580.
  13. Sowmya P. V., Boja Poojary, Revanasiddappa B. C., Vijayakumar M., Nikil P., Vasantha K., Novel 2-methyl-6-arylpyridines carrying active pharmacophore 4,5-dihydro-2-pyrazolines: synthesis, antidepressant and anti-tuberculosis evaluation. Res. Chem. Intermed.2017, 43, 7399–7422.